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| CAS号: | 1374601-40-7 |
| 英文名称: | BRD4770 |
| 英文同义词: | BRD4770;methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate;2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid methyl ester;methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate BRD4770 |
| 中文名称: | |
| 中文同义词: | |
| CBNumber: | CB02728540 |
| 分子式: | C25H23N3O3 |
| 分子量: | 0 |
| MOL File: | Mol file |
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BRD4770 性质、用途与生产工艺 |
生物活性
BRD4770是一种histone methyltransferase G9a抑制剂，其IC50为6.3 μM，并且会诱导细胞死亡。
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体外研究
BRD4770 reduces cellular levels of di- and trimethylated H3K9 via inhibition of G9a, induces senescence, and inhibits both anchorage-dependent and -independent proliferation in the pancreatic cancer cell line PANC-1. The combination of gossypol and BRD4770 increases LC3-II levels and the autophagosome number, and thus acts in synergy to induce cell death in PANC-1 cells.
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| BRD4770 上下游产品信息 |
上游原料
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下游产品
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| 1374601-40-7, BRD4770 相关搜索: |
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1374601-40-7
2-(Benzoylamino)-1-(3-phenylpropyl)-1H-benzimidazole-5-carboxylic acid methyl ester
methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate BRD4770
methyl 2-benzamido-1-(3-phenylpropyl)-1H-benzo[d]imidazole-5-carboxylate
BRD4770
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