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| CAS号: | 950455-15-9 |
| 英文名称: | Liproxstatin-1 |
| 英文同义词: | Liproxstatin-1;N-[(3-chlorophenyl)methyl]-spiro[piperidine-4,2'(1'H)-quinoxalin]-3'-amine |
| 中文名称: | Liproxstatin-1 |
| 中文同义词: | |
| CBNumber: | CB12744611 |
| 分子式: | C19H21ClN4 |
| 分子量: | 0 |
| MOL File: | Mol file |
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Liproxstatin-1 性质、用途与生产工艺 |
生物活性
Liproxstatin-1 是一种有效的 ferroptosis 抑制剂。
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体外研究
Liproxstatin-1 is able to inhibit ferroptosis in the low nanomolar range and inhibit the growth of Gpx4−/−cells with IC50 of 22 nM. Liproxstatin-1 (50 nM) completely prevents lipid peroxidation in Gpx4−/−cells. Liproxstatin-1 (200 nM) protects against FINs, such as BSO (10 µM), erastin (1 µM) and RSL3 (0.5 µM), in a dose dependent manner, whereas it fails to rescue cell death induced by staurosporine (0.2 µM) and H2O2 (200 µM).
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体内研究
Liproxstatin-1 remarkably extends survival compared with the vehicle-treated group, delays ferroptosis in tubular cells, and mitigates tissue injury in ischaemia/reperfusion-induced liver injury.
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| Liproxstatin-1 上下游产品信息 |
上游原料
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下游产品
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