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Patupilone

CAS No.152044-54-7
Chemical Name:Patupilone
Synonyms:EPO 906A;Patupilone;EPOTHILONE;Epothilone B;Epothilone B(EPO906);Epothilone B(Patupilone);Epothilone B HOUSE STANDARD;Epothilone B (EPO906, Patupilone);()-Epothilone B,EPO906, EpoB, Patupilone;(3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentaMethyl-3-((E)-1-(2-Methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dione
CBNumber:CB0972824
Molecular Formula:C27H41NO6S
Formula Weight:507.68
MOL File:152044-54-7.mol
Patupilone Property
mp : 95-97°C
density : 1.136
storage temp. : Store at -20°C
Safety

Patupilone Chemical Properties,Usage,Production

Chemical Properties
White Powder
Usage
Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division.
Usage
Epothilone B is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Like epothilone A, epothilone B acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity.
Biological Activity
Microtubule stabilization agent that promotes tubulin polymerization and induces G 2 -M cell cycle arrest (EC 50 = 3 - 92 nM). Potently inhibits a variety of human cancer cell lines (IC 50 values are 0.13 - 0.64 nM), including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent anticancer activity in numerous human tumor xenografts in vivo .
Patupilone Preparation Products And Raw materials
Raw materials
Preparation Products
Patupilone Suppliers      Global( 77)Suppliers     
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Chembest Research Laboratories Limited +86(0)21-20908456+86(0)21-58180499sales@biochembest.comCHINA 6000 61
CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512+86-510-68873513sales@cegchem.comCHINA 2050 58
Hubei Widely Chemical Technology Co., Ltd. 027-83778895 18827677254 18627097818027-83778895harry.t@foxmail.com 18827677254@163.comCHINA 308 64
Wuhan Bo-Sen Biological Technology Co., Ltd 027-51335350 15107175693027-51335350bosenyuan@foxmail.comCHINA 192 55
Shanghai Boyle Chemical Co., Ltd. Mr Qiu 86-21-50182298(Domestic Market)Miss Xu 86-21-50180596(Abroad Market)86-21-57758967sales@boylechem.comCHINA 5604 55
J & K SCIENTIFIC LTD. ----jkinfo@jkchemical.com;market3@jkchemical.comCHINA 96847 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:1893055203786-21-5032810967055399@qq.comCHINA 15983 69
Shijiazhuang Sdyano Fine Chemical Co., Ltd. +86-311-892503184000311741master@sjzsdyn.comCHINA 4980 65
BePharm Ltd. (Click here for a quote) 40068-59117; 86-21-51816456-8021/8022/8023+86-21-51816740 (China Mainland); +86-21-51816457 (Others)product@bepharm.comCHINA 24999 61
Nanjing Chemlin Chemical Co., Ltd 025-83697070; 010-68547217+86-25-83453306sales@chemlin.com.cnCHINA 20120 64
 
152044-54-7(Patupilone)Related Search:
IXABEPILONE Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (4S,7R,8S,9S,13Z,16S)- Amphotericin B Methylparaben 4-Hydroxybenzoic acid POLYOXIN B [4S-(4alpha,4aalpha,5aalpha,12aalpha)]-4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxonaphthacene-2-carboxamide monohydrochloride Gentamicin 10-Hydroxycamptothecin Doxycycline Glycolic acid Glycolonitrile Clindamycin Lincomycin Solvent Red 43 Azithromycin Rapamycin p-Hydroxybenzaldehyde
152044-54-7 4,17-Dioxabicyclo14.1.0heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (1S,3S,7S,10R,11S,12S,16R)- EPO 906A Inhibitors (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione Epothilone B Patupilone ()-Epothilone B,EPO906, EpoB, Patupilone Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds Epothilone B(EPO906) Epothilone B HOUSE STANDARD Epothilone B(Patupilone) (3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentaMethyl-3-((E)-1-(2-Methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dione Epothilone B (EPO906, Patupilone) EPOTHILONE (1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione Patupilone (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
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