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CAS No. | 152044-54-7 |
Chemical Name: | Patupilone |
Synonyms: | EPO 906A;Patupilone;EPOTHILONE;Epothilone B;Epothilone B(EPO906);Epothilone B(Patupilone);Epothilone B HOUSE STANDARD;Epothilone B (EPO906, Patupilone);()-Epothilone B,EPO906, EpoB, Patupilone;(3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentaMethyl-3-((E)-1-(2-Methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dione |
CBNumber: | CB0972824 |
Molecular Formula: | C27H41NO6S |
Formula Weight: | 507.68 |
MOL File: | 152044-54-7.mol |
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Patupilone Property |
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storage temp. : |
Store at -20°C |
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Patupilone Chemical Properties,Usage,Production |
Chemical Properties
White Powder |
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Usage
Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division.
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Usage
Epothilone B is a microtubule inhibitor isolated from the myxobacteria, Sorangium cellulosum. Like epothilone A, epothilone B acts by stabilising microtubule formation at the taxol binding site, and causes cell cycle arrest at the G2/M transition, leading to cytotoxicity. |
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Biological Activity
Microtubule stabilization agent that promotes tubulin polymerization and induces G 2 -M cell cycle arrest (EC 50 = 3 - 92 nM). Potently inhibits a variety of human cancer cell lines (IC 50 values are 0.13 - 0.64 nM), including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent anticancer activity in numerous human tumor xenografts in vivo . |
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Patupilone Preparation Products And Raw materials |
Raw materials
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Preparation Products
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Patupilone Suppliers Global( 77)Suppliers |
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152044-54-7
4,17-Dioxabicyclo14.1.0heptadecane-5,9-dione, 7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl-, (1S,3S,7S,10R,11S,12S,16R)-
EPO 906A
Inhibitors
(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
Epothilone B
Patupilone
()-Epothilone B,EPO906, EpoB, Patupilone
Chiral Reagents
Intermediates & Fine Chemicals
Pharmaceuticals
Sulfur & Selenium Compounds
Epothilone B(EPO906)
Epothilone B HOUSE STANDARD
Epothilone B(Patupilone)
(3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentaMethyl-3-((E)-1-(2-Methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dione
Epothilone B (EPO906, Patupilone)
EPOTHILONE
(1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione
Patupilone
(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
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