|
|
| CAS No. | 131436-22-1 |
| Chemical Name: | Cercosporamide |
| Synonyms: | Cercosporamide;4-Dibenzofurancarboxamide;Cercosporamide from Cercosporidium henningsii;(R)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9aβ-methyl-9-oxodibenzofuran-4-carboxamide |
| CBNumber: | CB11120153 |
| Molecular Formula: | C16H13NO7 |
| Formula Weight: | 331.279 |
| MOL File: | 131436-22-1.mol |
|
|
|
|
Cercosporamide Chemical Properties,Usage,Production |
Usage
Cercosporamide is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2) and JAK3. Cercosporamide effectively inhibits eIF4E phosphorylation as well as inibitiing inhibits Pkc1. Cercosporamide displays antiproliferative and proapoptotic activity in cancer cells in vitro. |
|
Usage
Cercosporamide was originally identified as a host-selective phytotoxin and broad spectrum antifungal agent isolated from Cercosporidium henningsii. More recently, cercosporamide was shown to inhibit a cell wall integrity pathway mediated through a serine/threonine protein kinase, Pkc1, that is central to cell wall biosynthesis. It is both a potent (IC50<50nM) and selective inhibitor of Pkc1 kinase. |
|
|
| Cercosporamide Preparation Products And Raw materials |
Raw materials
|
Preparation Products
|
| Cercosporamide Suppliers Global( 11)Suppliers |
|
|
|
|
|
|
131436-22-1
Cercosporamide
(R)-8-Acetyl-9,9a-dihydro-1,3,7-trihydroxy-9aβ-methyl-9-oxodibenzofuran-4-carboxamide
Heterocycles
Inhibitors
Intermediates & Fine Chemicals
Pharmaceuticals
Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
4-Dibenzofurancarboxamide
Cercosporamide from Cercosporidium henningsii
|