3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid

CAS No.	252916-29-3
Chemical Name:	3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
Synonyms:	TSU-68;Orantinib;NSC 702827;TSU-68 (SU6668);SU 6668(TSU-68);TSU-68 (SU6668, Orantinib);3-(2,4-DiMethyl-5-((2-oxoindolin-3-ylidene)Methyl)-1H-pyrrol-3-yl)propanoic acid;(E)-3-(2,4-diMethyl-5-((2-oxoindolin-3-ylidene)Methyl)-1H-pyrrol-3-yl)propanoic acid;(Z)-3-(2,4-dimethyl-5-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid;3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid
CBNumber:	CB31456201
Molecular Formula:	C18H18N2O3
Formula Weight:	0
MOL File:	252916-29-3.mol

3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid Property

storage temp. :

Store at RT

Safety

3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid Chemical Properties,Usage,Production

Usage
TSU-68 (SU6668, Orantinib) is a potent inhibitor of Flk-1/KDR, FGFR1 and PDGFRβ with Ki of 2.1 μM, 1.2 μM, and 8 nM, respectively.

Usage
TSU-68 is a inhibitor that targets vascular endothelial growth factor receptor 2, platelet-derived growth factor receptor β, and fibroblast growth factor receptor 1. The inhibitory effects of TSU-68 t owards these growth factors lead to substantial antitumor activity and showed potential in its development in therapeutic uses.

Biological Activity
ATP-competitive PDGFR, VEGF and FGFR inhibitor (IC 50 values are 0.06, 2.43, 3.04 and > 100 μ M at PDGFR β , VEGFR2, FGFR1 and EGFR respectively). Inhibits proliferation of HUVEC and NIH3T3 cells in vitro (IC 50 values are 0.41, 9.3 and 16.5 μ M for VEGF, FGF and PDGF-stimulated growth respectively) and induces > 75% growth inhibition against a broad range of tumor types in vivo . Exhibits antiangiogenic, anti-inflammatory, antimetastatic and proapoptotic activity and is orally active.

3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid Suppliers Global( 52)Suppliers

Supplier	Tel	Fax	Email	Country	ProdList	Advantage
Ketenechem (Shanghai) Co,. Ltd.	021-61315236	021-58958628	sales@ketenechem.com	CHINA	50	58
Shanghai Boyle Chemical Co., Ltd.	Mr Qiu 86-21-50182298(Domestic Market)Miss Xu 86-21-50180596(Abroad Market)	86-21-57758967	sales@boylechem.com	CHINA	5604	55
J & K SCIENTIFIC LTD.	--	--	jkinfo@jkchemical.com;market3@jkchemical.com	CHINA	96847	76
3B Pharmachem (Wuhan) International Co.,Ltd.	86-21-50328103 * 801、802、803、804 Mobile:18930552037	86-21-50328109	67055399@qq.com	CHINA	15983	69
ZHIWE CHEMTECH CO LTD	021-20221225;13917446399；QQ:2381298399		sales@zhiwe.net;zwchem@163.com	CHINA	297	61
Chembest Research Laboratories Limited	+86(0)21-20908456	+86(0)21-58180499	sales@biochembest.com	CHINA	6000	61
Shijiazhuang Sdyano Fine Chemical Co., Ltd.	+86-311-89250318	4000311741	master@sjzsdyn.com	CHINA	4980	65
VDM Biochemicals	0330-2528181	0330-2528171	sales@vdmbio.com	USA	511	64
Jinan Trio PharmaTech Co., Ltd.	+86 (531) 88811793；+86 (531) 88811783;+(0)18854807083;	+86 (531) 55696010 QQ981200479	sales@trio-pharmatech.com (International market);trio@trio-pharmatech.com(Domestic market)	CHINA	1779	62
Shanghai Feibo Chemical Technology Co., Ltd	+86 (21) 5895-5608	+86 (21) 5895-5916	sales@arknano.com	CHINA	1863	62

252916-29-3(3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid)Related Search:

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252916-29-3 3-[2,4-dimethyl-5-[(E)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid Angiogenesis and Metastasis TSU-68 API 5-[1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid (Z)-3-(2,4-dimethyl-5-((2-oxoindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid TSU-68 (SU6668) 1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl- SU 6668(TSU-68) (E)-3-(2,4-diMethyl-5-((2-oxoindolin-3-ylidene)Methyl)-1H-pyrrol-3-yl)propanoic acid NSC 702827 TSU-68 (SU6668, Orantinib) Orantinib 3-(2,4-DiMethyl-5-((2-oxoindolin-3-ylidene)Methyl)-1H-pyrrol-3-yl)propanoic acid 5-[1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic acid TSU-68 (SU6668, Orantinib)