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CAS番号. | 341031-54-7 |
化学名: | |
别名: | |
英語化学名: | N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate |
英語别名: | SU112248;SU 011248;Malic acid Shu;SUNITINIB MALATE;Sunitinib Mablate;Sunitinib Malate(Sutent);EZSolution Sunitinib Malate;N-(2-(DiethylaMino)ethyl)-5-((Z)-(5-fluoro-1,2-dih;(Z)-N-(2-(diethylaMino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)Methyl)-2,4-diMethyl-1H-pyrrole-3-carboxaMide (S)-2-hydroxysuccinate;(Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide ,(S)-2-hydroxysuccinic acid |
CBNumber: | CB22131216 |
分子式: | C22H27FN4O2.C4H6O5 |
分子量: | 532.566 |
MOL File: | 341031-54-7.mol |
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N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate 物理性質 |
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N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate 化学特性,用途語,生産方法 |
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使用
Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. |
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使用
Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit |
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使用
A multi-kinase inhibitor targeting several receptor tyrosine kinases (RTK). Antineoplastic. |
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生物活性
Potent, ATP-competitive VEGFR, PDGFR β and KIT inhibitor (K i values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFR β and KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models. |
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N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate 上流と下流の製品情報 |
原材料
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準備製品
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N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate 生産企業 Global( 92)Suppliers |
名前 | 電話番号 | ファックス番号 | 電子メール | 国籍 | 製品カタログ | 優位度 |
Zhengzhou Topcare Pharmaceutical Co.,Ltd.
| 0371-60942985,15839104947 | 0371-60942986,qq1994339443 | marketing@topcarepharm.com.cn | CHINA |
48
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58
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Nanjing First Pharmaceutical Co., Ltd.
| +86-25-83172655 /13776562784 | +86-25-86501191 | sales@njfirstpharm.com | CHINA |
123
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60
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Nanjing distinctions Medical Technology Co., Ltd.
| 025-84933953 13914714059 | 025-84933951 | info@keyopharm.com | CHINA |
35
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56
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Wuhan Biocar Bio-Pharm Co., Ltd.
| 027-86335551 | 86-027-87050469 | newbio@biocar.cn | CHINA |
1813
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50
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J & K SCIENTIFIC LTD.
| -- | -- | jkinfo@jkchemical.com;market3@jkchemical.com | CHINA |
96847
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76
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Chemfun Medical Technology(Shanghai) Co., Ltd.
| 021-67220633 & 021-37212706 | +86-21-67220638 | chemfun@chemfun.net | CHINA |
21915
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59
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Beijing Lunarsun Pharmaceutical Co.,LTD.
| 86-10-80771328 80771377、78、79 | 86-10-80771338 | sales@lunarsun.com.cn | CHINA |
118
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60
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Nanjing Chemlin Chemical Co., Ltd
| 025-83697070; 010-68547217 | +86-25-83453306 | sales@chemlin.com.cn | CHINA |
20120
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64
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Chemsky(shanghai)International Co.,Ltd.
| 021-50135380 | | shchemsky@sina.com | CHINA |
32553
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50
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Shanghai Excellent Chemical Co., Ltd.
| 0086-21-33559231; 018964673308 qq48685515;Skype: excellentchem | 0086-21-33559231 | sales@excellentchem.com | CHINA |
2111
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59
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341031-54-7
SUNITINIB MALATE
N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate
N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide(2S)-2-hydroxybutanedioatesalt
Sunitinib Malate(Sutent)
Butanedioic acid, 2-hydroxy-, (2S)-, coMpd. with N-[2-(diethylaMino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-1H-pyrrole-3-carboxaMide (1:1)
N-(2-(DiethylaMino)ethyl)-5-((Z)-(5-fluoro-1,2-dih
Butanedioic acid, 2-hydroxy-, (2S)-, coMpd. with N-[2-(diethylaMino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-1H-pyrrole-3-carboxaMide
(Z)-N-(2-(diethylaMino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)Methyl)-2,4-diMethyl-1H-pyrrole-3-carboxaMide (S)-2-hydroxysuccinate
Sunitinib Mablate
(Z)-N-(2-(diethylamino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide ,(S)-2-hydroxysuccinic acid
Sunitinib malate N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate
Malic acid Shu
N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-2-hydroxybutanedioic acid (1:1) salt
SU 011248
SU112248
EZSolution Sunitinib Malate
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