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エプレレノン

CAS番号.107724-20-9
化学名:エプレレノン
别名:エプレレノン
英語化学名:Eplerenone
英語别名:Inspra;SC-66110;CGP 30083;HSDB 7522;EPLERINONE;EPLERENONE;Elperenone;epoxymexrenone;EPLERENONE 98%;Eplerenone-13C-d3
CBNumber:CB3489802
分子式:C24H30O6
分子量:414.49
MOL File:107724-20-9.mol
エプレレノン 物理性質
融点 : 241-243°C
貯蔵温度 : Store at RT
安全性情報
有毒物質データの: 107724-20-9(Hazardous Substances Data)

エプレレノン 化学特性,用途語,生産方法

化学的特性
White Solid
使用
Selective aldosterone receptor antagonist (SARA), structurally similar to Spiranolactone. Eplerenone is used alone or in combination with other medications to treat high blood pressure. Eplerenone is in a class of medications called mineralocorticoid receptor antagonists. It works by blocking the action of aldosterone, a natural substance in the body that raises blood pressure.
使用
Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM. It is used as an adjunct in the management of chronic heart failure. It is similar to the diuretic spironolactone, though it may be more specific for the mineralocorticoid receptor and is sp
使用
anticancer agent
生物活性
Selective mineralocorticoid (aldosterone) receptor antagonist (IC 50 = 360 nM). Displays > 27-fold selectivity over androgen, progesterone and estrogen receptors (IC 50 > 10 μ M). Orally active antihypertensive in vivo .
エプレレノン 上流と下流の製品情報
原材料
準備製品
エプレレノン 生産企業      Global( 181)Suppliers     
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107724-20-9(エプレレノン) キーワード:
テトラデカン二酸 トリデカン二酸 ヘキサデカン二酸 N-[(1S)-1-(エトキシカルボニル)-3-フェニルプロピル]-L-Ala-L-Pro-OH (-)-1-[N-[(S)-1-(エトキシカルボニル)-3-フェニルプロピル]-L-アラニル]-L-プロリン·マレイン酸 3,6-ビス(4-クロロ-2-ホスホノフェニルアゾ)-4,5-ジヒドロキシナフタレン-2,7-ジスルホン酸 トリオキシサレン
107724-20-9 (7A,11A,17A)-9,11-EPOXY-17-HYDROXY-3-OXO-PREGN-4-ENE-7,21-DICARBOXYLIC ACID G-LACTONE METHYL ESTER EPLERENONE EPLERINONE pregn-4-ene-7,21-dicarboxylic acid 9,11-epoxy-17-hydroxy-3-oxo gamma-lactone methyl ester EPLERENONE 98% EPLERENONE USP STANDARD Elperenone EplerenoneC24H3006 pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo, γ-lactone, methyl ester (7 α, 11 α, 17 α) EPLERENONE AND N-1 INTERMEDIATE epoxymexrenone (7a,11a,17a)-9,11-Epoxy-17-hydroxy-3-oxopregn-4-ene-7,21-dicarboxylic Acid -Lactone 7-Methyl Ester CGP 30083 Inspra SC-66110 CGP 30083, Epoxymexrenone, Inspra, Spiro[9,11-epoxy-9H-cyclopenta[a]phenanthrene-17(2H),2(3-furan],pregn-4-ene-7,21-dicarboxylic Acid, Inspra, (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxo-pregn-4-ene-7,21-dicarboxylicacidγ-lactonemethylester Methyl (1'R,2R,2'S,9'R,10'S,11'S,15'S,17'R)-2',15'-diMethyl-5,5'-dioxo-18'-oxaspiro[oxolane-2,14'-pentacyclo[8.8.0.0^{1,17}.0^{2,7}.0^{11,15}]octadecan]-6'-ene-9'-carboxylate (7α,11α,17α)-9,11-Epoxy-17-hydroxy-3-oxopregn-4-ene-7,21-dicarboxylic Acid γ-Lactone 7-Methyl Ester 9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic Acid gamma-Lactone Methyl Ester Eplerenone-13C-d3 (2'R,4aS,4bR,5aR,6aS,9aS,9bR,10R)-Methyl 4a,6a-diMethyl-2,4'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate (7α,11α,17α)-9,11-epoxy-17-hydroxy-3-oxo-γ-lactone-pregn-4-ene-7,21-dicarboxylic acid-7-methyl ester Eplerenone [USAN] HSDB 7522 Pregn-4-ene-7,21-dicarboxylic acid, 9,11-epoxy-17-hydroxy-3-oxo-, gamma-lactone, methyl ester, (7alpha,11alpha,17alpha)- エプレレノン
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