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Product Name:PiMecroliMus
CAS:137071-32-0
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Product Name:Pimecrolimus
CAS:137071-32-0
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CAS:137071-32-0
Package:100Mg,10Mg |
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Product Name:PiMecroliMus(Elidel, SDZ-ASM-981)
CAS:137071-32-0
Remarks:C14024 |
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| | Pimecrolimus Basic information |
| Product Name: | Pimecrolimus | | Synonyms: | Picrolimus;ASM 981;Elidel;SDZ-ASM 981;Pimecrolimus;15,19-Epoxy-3H-pyrido(2,1-C)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-((1E)-2-((1R,3R,4S)-4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26as)-;15,19-Epoxy-3H-pyrido(2,1-C)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-(2-(4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-, 5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26A-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-, (3S-(3R*(E(1S*,3S*,4R*)),4S*,5R*,8S*,9E,12R*,14R*,15S*,16R*,18S*,19S*,26ar*))-;Unii-7kyv510875 | | CAS: | 137071-32-0 | | MF: | C43H68ClNO11 | | MW: | 810.459 | | EINECS: | | | Product Categories: | Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Elidel, SDZ-ASM-981 | | Mol File: | 137071-32-0.mol |  |
| | Pimecrolimus Chemical Properties |
| density | 1.19 | | storage temp. | -20°C Freezer |
| | Pimecrolimus Usage And Synthesis |
| Chemical Properties | White Solid | | Usage | Pimecrolimus is a semi-synthetic, macrocyclic lactone derived from ascomycin by activation of the 32-hydroxy group with a triflate ester, and nucleophilic substitution with chloride under phase transfer conditions to provide the chloro analogue. Pimecrolimus has been targeted for treatment of inflammatory skin disorders. Like all tacrolimus analogues, pimecrolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Pimecrolimus is extensively cited in the literature with over 2,000 citations. | | Usage | Macrolactam ascomycin derivative; inhibits production of pro-inflammatory cytokines by T cells and mast cells. Immunosuppresant | | Usage | Pimecrolimus caused a strong and dose-dependent inhibition of anti-IgE–induced release of histamine from mast cells and basophils (maximally 73% and 82%, respectively, at 500 nmol/L pimecrolimus) and of mast cell tryptase (maximally 75%) and a less pronou |
| | Pimecrolimus Preparation Products And Raw materials |
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