| Company Name: | Dalian Meilun Biotech Co., Ltd. Gold |
| Tel: | 0411-66771943；0411-66771942 |
| Email: | sales@meilune.com |
| Products Intro: |
Product Name:WORTMANNIN
CAS:19545-26-7
Package:5Mg,25Mg,100Mg |
| Company Name: | J & K SCIENTIFIC LTD. |
| Tel: | 400-666-7788 +86-10-82848833 |
| Email: | jkinfo@jkchemical.com;market3@jkchemical.com |
| Products Intro: |
Product Name:WortMannin
CAS:19545-26-7
Purity:98% Package:10MG,1MG,5MG |
| Company Name: | Meryer (Shanghai) Chemical Technology Co., Ltd. |
| Tel: | +86-(0)21-61259100(Shanghai) +86-(0)755-86170099(ShenZhen) +86-(0)10-59487313(Beijing) |
| Email: | sh@meryer.com |
| Products Intro: |
Product Name:WortMannin
CAS:19545-26-7
Purity:98% Remarks:32859 |
| Company Name: | 3B Pharmachem (Wuhan) International Co.,Ltd. |
| Tel: | 86-21-50328103 * 801、802、803、804 Mobile:18930552037 |
| Email: | 67055399@qq.com |
| Products Intro: |
Product Name:WortMannin;(1S,6bR,9aS,11R,11bR)11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(MethoxyMethyl)-9a,11b-diMethyl-3H-furo[4,3,2-de]indeno[4,5,-h]-2-h]-2-benzopyran-3,6,9-trione
CAS:19545-26-7
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g |
|
| | WORTMANNIN Basic information |
| Product Name: | WORTMANNIN | | Synonyms: | antibioticsl-2052;sl-2052;[1S-(1ALPHA,6BALPHA,9ABETA,11ALPHA,11BBETA)]-11-(ACETYLOXY)-1,6B,7,8,9A,10,11,11B-OCTAHYDRO-1-(METHOXYMETHYL)-9A,11B-DIMETHYL-3H-FURO[4,3,2-DE]INDENO[4,5-H]-2-BENZOPYRAN-3,6,9-TRIONE;(1S,6BR,9AS,11R,11BR) 11-(ACETYLOXY)-1,6B,7,8,9A,10,11,11B-OCTAHYDRO-1-(METHOXYMETHYL)-9A,11B-DIMETHYL-3H-FURO[4,3,2-DE]INDENO[[4,5-H]-2-H]-2-BENZOPYRAN-3,6,9-TRIONE;KY 12420;PI 3-KINASE INHIBITOR;WORTMANNIN, PENICILLIUM WORTMANNI;WORTMANNIN | | CAS: | 19545-26-7 | | MF: | C23H24O8 | | MW: | 428.43 | | EINECS: | 214-538-0 | | Product Categories: | Antibiotics;Lipid signaling;Signalling;inhibitor;Anti-cancer&immunity | | Mol File: | 19545-26-7.mol |  |
| | WORTMANNIN Chemical Properties |
| mp | 234-240 °C
| | storage temp. | 2-8°C
| | solubility | DMSO: soluble
| | form | powder
| | color | off-white
| | Merck | 13,10110 |
| | WORTMANNIN Usage And Synthesis |
| Chemical Properties | White to pale yellow powder | | Usage | Wortmannin is a steroidal metabolite belonging to the viridin group, isolated from Penicillium wortmannii in 1957. The structure was finally solved in 1968. Wortmannin exhibits broad spectrum antifungal activity, together with antitumour and antiinflammatory activity. Wortmannin is a potent inhibitor of phosphoinositide 3-kinase and myosin light chain kinase. Wortmannin also activates neutrophil and formyl-Met-Leu-Phe-mediated phospholipase D, inhibits autophagy, potentiates LPS-induced NO production and induces Alzheimer-like hyperphosphorylation in tau in vivo. | | Usage | Wortmannin is a steroidal metabolite belonging to the viridin group, isolated from Penicillium wortmannii in 1957. The structure was finally solved in 1968. Wortmannin exhibits broad spectrum antifungal activity, together with antitumor and antiinflammatory activity. Wortmannin is a potent inhibitor of phosphoinositide 3-kinase and myosin light chain kinase. Wortmannin also activates neutrophil and formyl-Met-Leu-Phe-mediated phospholipase D, inhibits autophagy, potentiates LPS-induced NO production and induces Alzheimer-like hyperphosphorylation in tau in vivo. | | Biological Activity | Potent, selective, cell-permeable and irreversible inhibitor of phosphatidylinositol 3-kinase (PI 3-kinase) (IC 50 = 2-4 nM). Also potently inhibits polo-like kinase 1 (PLK1) (IC 50 = 5.8 nM). |
| | WORTMANNIN Preparation Products And Raw materials |
|