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CAS号: | 58152-03-7 |
英文名称: | Isepamicine |
英文同义词: | hapa-b;sch21420;isepamicin;ISEPAMICINE;hapa-gentamycinb;ISEPAMICIN SULPHATE;(s)-y-1-oxopropyl)-2-deoxy;thyl-3-(methylamino)-beta-l-arabinopyranosyl-(1-6))-n(sup1)-(3-amino-2-hydrox;4-O-(6-Amino-6-deoxy-α-D-glucopyranosyl)-6-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]-N1-[(S)-3-amino-2-hydroxypropanoyl]-2-deoxy-D-streptamine;4-O-(6-Amino-6-deoxy-α-D-glucopyranosyl)-6-O-[4-C-methyl-3-(methylamino)-3-deoxy-β-L-arabinopyranosyl]-N1-[(S)-3-amino-2-hydroxypropionyl]-2-deoxy-D-streptamine |
中文名称: | 异帕米星 |
中文同义词: | 异米帕星;异帕米星;(+)-氧-6-氨基-6-脱氧-Α-D-葡糖吡喃基-(1→4)-氧-[3-脱氧-4-碳-甲基-3-甲基氨基-Β-阿吡喃糖基-(1→6)]-2-脱氧-N^<1>^-[(S)-异丝氨酸基]-D-链霉胺 |
CBNumber: | CB3245233 |
分子式: | C22H43N5O12 |
分子量: | 569.6 |
MOL File: | 58152-03-7.mol |
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异帕米星 性质、用途与生产工艺 |
化学性质
硫酸异帕米星(Isepamiein Sulfate):C22H43N5O12?xH2SO4(x≤2)。[67814-76-0]。[α]{D}^26+110.9°(C=1,水中成为水合物)。急性毒性LD50雄、雌小鼠,雄、雌大鼠(mg/kg):3312,3320,3451,3392皮下注射;234,236,489,476静脉注射;全部>5000口服。
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用途
半合成氨基糖苷类抗生素。每日用药一次,对人安全性大。用于金黄色葡萄球菌、大肠杆菌、肺炎杆菌、绿脓杆菌等敏感菌引起的败血症、慢性支气管炎、支气管扩张症感染、肺炎、腹膜炎等。
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生产方法
3h e,过滤除去催化剂,滤液浓缩至干,用硅胶层析,以氯仿、甲醇和氯化铵的混合液洗脱。得化合物(Ⅲ)。 化合物(Ⅲ)和三氟乙酸反应后,加入过量的乙醚以产生沉淀。过滤收集该沉淀,用乙醚洗,再用硅胶柱层析,用氯仿一甲醇一氢氧化铵(1:1.5:1)洗脱。得0.352g异帕米星。按常法可转化为硫酸异帕米星。
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急性毒性
腹腔-小鼠 LDL0: 5000 毫克/公斤; 静脉-小鼠LD50: 330 毫克/公斤
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异帕米星 生产厂家 全球有 28家供应商
异帕米星国内生产厂家
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医药与生物化工
抗感染药物
药物
抗生素
氨基糖苷类抗生素
C22H43N5O12
(+)-氧-6-氨基-6-脱氧-Α-D-葡糖吡喃基-(1→4)-氧-[3-脱氧-4-碳-甲基-3-甲基氨基-Β-阿吡喃糖基-(1→6)]-2-脱氧-N^<1>^-[(S)-异丝氨酸基]-D-链霉胺
异米帕星
异帕米星
58152-03-7
4-O-(6-Amino-6-deoxy-α-D-glucopyranosyl)-6-O-[4-C-methyl-3-(methylamino)-3-deoxy-β-L-arabinopyranosyl]-N1-[(S)-3-amino-2-hydroxypropionyl]-2-deoxy-D-streptamine
4-O-(6-Amino-6-deoxy-α-D-glucopyranosyl)-6-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]-N1-[(S)-3-amino-2-hydroxypropanoyl]-2-deoxy-D-streptamine
4-O-(6-Amino-6-deoxy-α-D-glucopyranosyl)-6-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]-N1-[(S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-D-streptamine
(S)-O-6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->6)]-1,3-diamino-N1-(3-aminolactoyl)-1,2,3-trideoxy-D-scyllo-inositol
(S)-O-6-Amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyrano-syl-(1→6)]-N^<1>^-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-D-streptamine
(2S)-3-Amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-2-[(3R,4R,5R)-3,5-dihydroxy-5-methyl-4-methylaminooxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxypropanamide
ISEPAMICINE
D-Streptamine, O-6-amino-6-deoxy-a-D-glucopyranosyl-(14)-O-[3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(16)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy- (9CI)
D-Streptamine, O-6-amino-6-deoxy-a-D-glucopyranosyl-(14)-O-[3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(16)]-N1-(3-amino-2-hydroxy-1-oxopropyl)-2-deoxy-, (S)-
ISEPAMICIN SULPHATE
thyl-3-(methylamino)-beta-l-arabinopyranosyl-(1-6))-n(sup1)-(3-amino-2-hydrox
sch21420
isepamicin
hapa-gentamycinb
hapa-b
(s)-y-1-oxopropyl)-2-deoxy
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