(E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-on Produkt Beschreibung

CAS-Nr.	82-08-6
Bezeichnung:	(E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-on
Englisch Name:	ROTTLERIN
Synonyma:	(E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-on kamalin;ROTTLERIN;MALLOTOXIN;Rottlerin,98%;Rottlerin, 98% 10MG;4’,6’-trihydroxy-5’-methyl-methyl)-2;acetophenone,3’-((8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-6-yl);3'-[(8-CINNAMOYL-5,7-DIHYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-6-YL)METHYL]-2',4',6'-TRIHYDROXY-5'-METHYLACETOPHENONE;3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone;1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one
CBNumber:	CB4260488
Summenformel:	C30H28O8
Molgewicht:	516.54
MOL-Datei:	82-08-6.mol

(E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-on physikalisch-chemischer Eigenschaften

Schmelzpunkt::

200 °C

storage temp. :

2-8°C

CAS Datenbank:

82-08-6(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher:

R-Sätze::

20/21/22

S-Sätze::

36/37

WGK Germany :

RTECS-Nr.:

AM6913800

(E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-on Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
orange to brown powder

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-Sätze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Biologische Aktivit?t
Originally reported to inhibit PKC isoforms, with selectivity for PKC δ (K i values are 30, 42, 40, 3-6, 100, and 100 μ M for α , β , γ , δ , ε , λ respectively). Also reported to inhibit CAM kinase III. However, recently shown to inhibit a wide range of protein kinases, and most potently to inhibit PRAK and MAPKAP-K2 (IC 50 values are 1.9 and 5 μ M respectively). Also shown to act as a direct mitochondrial uncoupler.

(E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-on Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-on Anbieter Lieferant Produzent Hersteller Vertrieb Händler. Global( 43)Lieferanten

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J & K SCIENTIFIC LTD.	--	--	jkinfo@jkchemical.com;market3@jkchemical.com	CHINA	96847	76
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Beijing innoChem Science & Technology Co.,Ltd.	400-810-7969 010-59572699	010-59572688	ningzi.li@inno-chem.com.cn	CHINA	6219	55
9ding chemical ( Shanghai) Limited	4009209199	86-021-52271987	sales@9dingchem.com	CHINA	22684	55
Shanghai Tauto Biotech Co., Ltd	0086-21-51320588	0086-21-51320502	export2@tautobiotech.com	CHINA	4011	66
Synchem OHG	+49 5662 408730	+49 5662 4087320	info@synchem.de	GERMANY	4701	70
ChemStrong Scientific Co.,Ltd	0755 66853366	0755 28363542	sales@chem-strong.com;	CHINA	11269	56

82-08-6((E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-on)Verwandte Suche:

2'-Hydroxy-6'-methoxychalkon 2,2'-Methylendiphenol 2,4,6-Trimethylphenol 2,2'-Methylendi-p-kresol 4-Hydroxy-3,5-dimethylbenzaldehyd 2,4-Dimethylphloroglucin (E)-1-[6-[(3-Acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-on 2,4-Dihydroxy-3-methylbenzaldehyd 2-Hydroxy-5-methylacetophenon

MALLOTOXIN Cell Signaling and Neuroscience Cell Biology BioChemical 82-08-6 3'-[(8-CINNAMOYL-5,7-DIHYDROXY-2,2-DIMETHYL-2H-1-BENZOPYRAN-6-YL)METHYL]-2',4',6'-TRIHYDROXY-5'-METHYLACETOPHENONE Serine/Threonine Kinase Inhibitors 4’,6’-trihydroxy-5’-methyl-methyl)-2 acetophenone,3’-((8-cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-6-yl) kamalin Kinase/Phosphatase Biology Protein Kinase C, Calcium/Calmodulin-dependent protein Kinase (PKC and CaMK) ROTTLERIN (E)-1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one C30H28O8 2-Propen-1-one, 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl]-3-phenyl-, (2E)- 1-[6-[(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)methyl]-5,7-dihydroxy-2,2-dimethyl-2h-1-benzopyran-8-yl]-3-phenyl-2-propen-1-one Aromatic Phenols Protein Kinase 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone Rottlerin,98% 1982-8-6 Rottlerin, 98% 10MG