kijanimicin Chemical Properties,Usage,Production |
Usage
Kijanimicin is a tetronic acid related to saccharocarcin, chlorothricin, versipelostatin and tetrocarcin. Like the tetrocarcins, kijanimicin contains an unusual nitroaminoglycoside. Kijanimicin is a potent antibacterial, antimalarial and antitumour active. Several members of this class have received considerable literature focus. Versipelostatin inhibits transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action is seen only in conditions of glucose deprivation and causes selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signalling pathway. |
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Usage
Kijanimicin is a tetronic acid related to saccharocarcin, chlorothricin, versipelostatin and tetrocarcin. Like the tetrocarcins, kijanimicin contains an unusual nitroaminoglycoside. Kijanimicin is a potent antibacterial, antimalarial and antitumor active. Several members of this class have received considerable literature focus. Versipelostatin inhibits transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action is seen only in conditions of glucose deprivation and causes selective and massive killing of the glucose-deprived cells. Tetrocarcin A appears to target the phosphatidylinositide-3'-kinase/Akt signalling pathway. |
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Raw materials
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Preparation Products
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