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Brefeldin A

CAS No.20350-15-6
Chemical Name:Brefeldin A
Synonyms:BFA;CYANEIN;DECUMBIN;cyanaein;ASCOTOXIN;Brefeldin;NSC 89671;NECTROLIDE;NSC 244390;NSC 107456
CBNumber:CB0689753
Molecular Formula:C16H24O4
Formula Weight:280.36
MOL File:20350-15-6.mol
Brefeldin A Property
mp : 200-205 °C
alpha : 93 º (C=2 IN MEOH)
Fp : 87 °C
storage temp. : 2-8°C
solubility : methanol: 10 mg/mL, clear, colorless to faintly yellow
Merck : 13,1355
Safety
Hazard Codes : Xn,T
Risk Statements : 22-25-36/37/38-20/21/22
Safety Statements : 24/25-45-36-26
RIDADR : UN 2811 6.1/PG 3
WGK Germany : 3
RTECS : GY8410000
HS Code : 29411090

Brefeldin A Chemical Properties,Usage,Production

Chemical Properties
White Powder
Usage
A macrolide isolated from Penicillium brefeldianum. It affects the vesticular transport of the Golgi apparatus and induces DNA fragmentation which leads to apoptosis
Usage
Brefeldin A is a potent inhibitor of cell growth first described in 1958, then independently rediscovered by several groups as a potent active in a broad range of bioassays. Brefeldin has antiviral, antibiotic, antifungal, antitumour and herbicidal activity. Early studies on the mode of action of brefeldin identified inhibition of protein and nucleic acid synthesis by disruption of the Golgi apparatus. The precise molecular target is a subset of Sec7-type GTP exchange factors (GEFs) that activate a small GTPase, Arf1p, an integral component of protein trafficking and signalling.
Usage
Brefeldin A is a potent inhibitor of cell growth first described in 1958, then independently rediscovered by several groups as a potent active in a broad range of bioassays. Brefeldin has antiviral, antibiotic, antifungal, antitumor and herbicidal activity. Early studies on the mode of action of brefeldin identified inhibition of protein and nucleic acid synthesis by disruption of the Golgi apparatus. The precise molecular target is a subset of Sec7-type GTP exchange factors (GEFs) that activate a small GTPase, Arf1p, an integral component of protein trafficking and signalling.
Biological Activity
Reversible inhibitor of protein translocation from the endoplasmic reticulum (ER) to the Golgi apparatus. Blocks binding of ADP-ribosylation factor to the Golgi apparatus and inhibits GDP-GTP exchange.
Brefeldin A Preparation Products And Raw materials
Raw materials
Preparation Products
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20350-15-6(Brefeldin A)Related Search:
BREFELDIN A, [3H],BREFELDIN-A, [7-3H] FEMA 2194 5-METHYL-HEX-2-ENOIC ACID ETHYL ESTER ETHYL TRANS-2-OCTENOATE Methyl acrylate Thiophanate-methyl Tylosin tartrate Parathion-methyl Brefeldin A Abamectin Ivermectin Nystatin Methyl Kresoxim-methyl Methyl bromide Methyl acetate Doramectin Bensulfuron methyl
NECTROLIDE SYNERGISIDIN 4h-cyclopent(f)oxacyclotridecin-4-one,1,6,7,8,9,11a-beta,12,13,14,14a-alpha-de cahydro-1-beta-13-alpha-dihydroxy-6-beta-methyl- cyanaein CYANEIN DECUMBIN GAMMA-4-DIHDYROXY-2-(6-HYDROXY-1-HEPTENYL)-4-CYCLOPENTANECROTONIC ACID LAMBDA-LACTONE GAMMA,4-DIHYDROXY-2-[6-HYDROXY-1-HEPTENYL]-4-CYCLOPENTANECROTONIC ACID LAMBDA-LACTONE BFA (+)-BREFELDIN A, EUPENICILLIUM BREFELDIANUM BREFELDIN A, EUPENICILLIUM BREFELDIANUM (+)-BREFELDIN A BREFELDIN A ASCOTOXIN 1,6,7,8,9,11A,12,13,14,14A-DECAHYDRO-1,13-DIHYDROXY-6-METHYL-4H-CYCLOPENT[F]OXACYCLOTRIDECIN-4-ONE 1,6,7,8,9,11AB,12,13,14,14AA-DECAHYDRO-1B,13A-DIHYDROXY-6B-METHYL-4H-CYCLOPENT(F)OXACYCLOTRIDECIN-4-ONE Antibiotics Antibiotics A to Z Antibiotics A-F BioChemical 20350-15-6 BREFELDIN A, MOLECULAR BIOLOGY REAGENT BREFELDIN A FROM PENICILLIUM BREFELDIANUM Brefeldin A, natural C16H24O4 20350-16-6 g-4-Dihdyroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic Acid, Lactone, BFA, Cyanein, Ascotoxin, Decumbin Brefeldin 4H-Cyclopentfoxacyclotridecin-4-one, 1,6,7,8,9,11a,12,13,14,14a-decahydro-1,13-dihydroxy-6-methyl-, (1R,2E,6S,10E,11aS,13S,14aR)- (+)-Brefeldin A, Ascotoxin, Cyanein, Decumbin, Nectrolide, Synergisidin -4-Dihdyroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic Acid, -Lactone, BFA, Cyanein, Ascotoxin, Decumbin All Inhibitors Inhibitors Intermediates & Fine Chemicals Pharmaceuticals Ascotoxin, BFA, Cyanein, Decumbin, γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone 4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone BFA / Ascotoxin / Cyanein / Decumbin Signalling BREFELDIN ARESEARCH GRADE BrefeldinA,γ,4-Dihydroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic acid λ-lactone, Ascotoxin, BFA, Cyanein, Decumbin Brefeldin A(BFA,Ascotoxin,Cyanein) NSC 244390 NSC 89671 Brefeldin A(BFA) NSC 107456 (1R,2E,6S,10E,11aS,13S,14aR)-1,13-dihydroxy-6-Methyl-6,7,8,9,12,13,14,14a-octahydro-1H-cyclopenta[f][1]oxacyclotridecin-4(11aH)-one antibiotic Ascotoxin, Cyanein, DecuMbin Brefeldin A, FroM EupenicilliuM brefeldianuM Brefeldin A Cyanein Ascotoxin
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