Chinese  Japanese  Germany

ChemicalBook >> CAS DataBase List >> SB 203580

SB 203580

CAS No.152121-47-6
Chemical Name:SB 203580
Synonyms:PB 203580;SB 203580;RWJ 64809;SB 203580 HYDROCHLORIDE;4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL) 1H-IMIDAZOLE;4-(4'-Fluorophenyl)-2-(4'-methylsulphinylphenyl)-5-(4'-pyridyl)imidazole;4-[5-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-3H-IMIDAZOL-4-YL]PYRIDINE;4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULFONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE;4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL)1H-IMIDAZOLE, HCL;4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine
CBNumber:CB1680333
Molecular Formula:C21H16FN3OS
Formula Weight:377.43
MOL File:152121-47-6.mol
SB 203580 Property
mp : 144-146
storage temp. : −20°C
solubility : DMSO: 50 mg/mL
form : solid
color : white to off-white
Stability:: -200C
CAS DataBase Reference: 152121-47-6(CAS DataBase Reference)
Safety
Hazard Codes : Xn
Risk Statements : 22-41
Safety Statements : 26-39
WGK Germany : 3

SB 203580 Chemical Properties,Usage,Production

Chemical Properties
White to Off-White Solid
Usage
A pyridinyl imidazole which acts as a specific inhibitor of p38 MAP kinase. Does not inhibit the MAP kinase homologs JNK and p42 MAP kinase
Usage
A p38 MAPK inhibitor with an IC50 range of 0.3-0.5 μM and blocks PKB phosphorylation with an IC50 range of 3-5 μM.
Biological Activity
Water-soluble salt of SB 203580 (4-[5-(4-Fluorophenyl)-2-[4-(methylsulfonyl)phenyl]-1H-imidazol-4-yl]pyridine ). Selective inhibitor of p38 mitogen-activated protein kinase (IC 50 values are 50 and 500 nM for SAPK2a/p38 and SAPK2b/p38 β 2 respectively). Displays 100-500-fold selectivity over LCK, GSK3 β and PKB α . Shown to inhibit interleukin-2-induced T-cell proliferation, cyclooxygenase-1 and -2, and thromboxane synthase.
SB 203580 Preparation Products And Raw materials
Raw materials
Preparation Products
SB 203580 Suppliers      Global( 82)Suppliers     
SupplierTelFaxEmailCountryProdListAdvantage
Shanghaizehan biopharma technology co., Ltd. 0086-021-61350663 130521174650086-021-61350662sales@zehanbiopharma.comCHINA 498 55
Beijing Dependence Chemistry Co., Ltd. +86 (10) 60279497+86 (10) 60279497sales@dcechem.comCHINA 20 58
Shanghai Boyle Chemical Co., Ltd. Mr Qiu 86-21-50182298(Domestic Market)Miss Xu 86-21-50180596(Abroad Market)86-21-57758967sales@boylechem.comCHINA 5604 55
J & K SCIENTIFIC LTD. ----jkinfo@jkchemical.com;market3@jkchemical.comCHINA 96847 76
3B Pharmachem (Wuhan) International Co.,Ltd. 86-21-50328103 * 801、802、803、804 Mobile:1893055203786-21-5032810967055399@qq.comCHINA 15983 69
Chembest Research Laboratories Limited +86(0)21-20908456+86(0)21-58180499sales@biochembest.comCHINA 6000 61
Ascent Scientific 44011798299884402030 700 369customerservice@ascentscientific.co.ukUNITED KINGDOM 282 60
Shanghai Yuanding Chem. Sci. & Tech. Co., Ltd. +86 (21) 5772-1279，+86 (21) 6775-2378+86 (21) 6775-2378，QQ：14057904sales@shydchem.com.cn, sales@shydtec.comCHINA 925 56
Chemfun Medical Technology(Shanghai) Co., Ltd. 021-67220633 & 021-37212706+86-21-67220638chemfun@chemfun.netCHINA 21915 59
VDM Biochemicals 0330-25281810330-2528171sales@vdmbio.comUSA 511 64
 
152121-47-6(SB 203580)Related Search:
U0126-EtOH MK-2206 2HCl 1,9-Pyrazoloanthrone PD 98059 SCH772984 LY 294002 HYDROCHLORIDE SB-203580 IN SOLUTION P38 INHIBITOR (SB 203580),SAPK2 INHIBITOR (SB 203580) SB 203580, 99+% SB 203580, IODO- SB 203580, SULFONE 2-(4-METHYLSULFANYL-PHENYL)-1H-IMIDAZOLE 4-(3H-Imidazol-4-yl)-pyridine SB 203580 2,4-Diphenylimidazole 4-METHYL-2,5-DIPHENYLIMIDAZOLE 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFONYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE
SB 203580 SB 203580 HYDROCHLORIDE Kinase/Phosphatase Biology MAPK-Activated Protein Kinase (MAPKAP Kinase) Serine/Threonine Kinase Inhibitors 152121-47-6 Cell Signaling and Neuroscience Cell Biology BioChemical 4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL) 1H-IMIDAZOLE 4-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-5-(4-PYRIDYL)1H-IMIDAZOLE, HCL 4-[5-(4-FLUOROPHENYL)-2-(4-METHYLSULFINYLPHENYL)-3H-IMIDAZOL-4-YL]PYRIDINE 4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULFONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE 4-[5-(4-FLUOROPHENYL)-2-[4-(METHYLSULPHONYL)PHENYL]-1H-IMIDAZOL-4-YL]PYRIDINE HYDROCHLORIDE 4-[5-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-4-yl]pyridine 4-[4-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]pyridine PB 203580 Pyridine, 4-[4-(4-fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-5-yl]- C21H16FN3OS pharmacetical 4-(4'-Fluorophenyl)-2-(4'-methylsulphinylphenyl)-5-(4'-pyridyl)imidazole Intermediates & Fine Chemicals Pharmaceuticals Protein Kinase Signalling C21H16FN3OSHCl Selective inhibitor of p38 mitogen-activated protein kinase. RWJ 64809 inhibitor 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole SB 203580 SB 203580 4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole
Copyright 2016 © ChemicalBook. All rights reserved