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TANDOSPIRONE

CAS No.87760-53-0
Chemical Name:TANDOSPIRONE
Synonyms:Sediel;TANDOSPIRONE;(3aR,4S,7R,7aS)-rel-;Tandospirone [inn:ban];Tandospirone hydrochloride;3a,4,7,7a-Hexahydro-2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-4,7-methano-1H-isoindole-1,3(2H)-dione;(1R*,2S*,3R*,4S*)-N-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl)-2,3-norbornanedicarboximide citrate salt;(3αα，4β，7β，7αα)-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4，7-methano-1H-isoindole-1，3(2H)-dione;4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aa,4b,7b,7aa)-;4,7-Methano-1H-isoindole-1,3(2H)-dione,hexahydro-2-[4-[4-(2-pyriMidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-rel-
CBNumber:CB4796484
Molecular Formula:C21H29N5O2
Formula Weight:383.49
MOL File:87760-53-0.mol
TANDOSPIRONE Property
storage temp. : Store at +4°C
Safety
Hazard Codes : Xi
Risk Statements : 36/37/38
Safety Statements : 26

TANDOSPIRONE Chemical Properties,Usage,Production

Usage
Tandospirone is a 5HT1A receptor partial agonist. Studies indicate that tandospirone significantly reduces haloperidol-induced bradykinesia in a dose dependent manner. The potency of Tandospirone is equal to that of buspirone and approximate one-half that of diazepam. The potency of Tandospirone at dopamine antagonistic action is less than 1/4 that of buspirone.
Biological Activity
5-HT 1A receptor partial agonist (K i = 27 nM) that displays selectivity over 5-HT 2 , 5-HT 1C , α 1 , α 2 , D 1 and D 2 receptors (K i values ranging from 1300-41000 nM). Inactive at 5-HT uptake sites, 5-HT 1B , β -adrenergic, muscarinic and benzodiazepine receptors. Displays anxiolytic activity.
TANDOSPIRONE Preparation Products And Raw materials
Raw materials
2-(1-Piperazinyl)pyrimidine Borneol
Preparation Products
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87760-53-0(TANDOSPIRONE)Related Search:
tandospirone citrate TANDOSPIRONE
87760-53-0 TANDOSPIRONE C21H29N5O2 4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aa,4b,7b,7aa)- 4,7-Methano-1H-isoindole-1,3(2H)-dione, hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-rel- (9CI) Serotonin receptor (3αα，4β，7β，7αα)-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4，7-methano-1H-isoindole-1，3(2H)-dione Sediel 3a,4,7,7a-Hexahydro-2-(4-(4-(2-pyrimidinyl)-1-piperazinyl)butyl)-4,7-methano-1H-isoindole-1,3(2H)-dione Tandospirone [inn:ban] (3aR,4S,7R,7aS)-rel-Hexahydro-2-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-4,7-methano-1H-isoindole-1,3(2H)-dionehydrochloride Tandospirone hydrochloride C21H29N5O2HCl Aromatics Heterocycles Intermediates & Fine Chemicals Pharmaceuticals (3aR,4S,7R,7aS)-rel- 4,7-Methano-1H-isoindole-1,3(2H)-dione,hexahydro-2-[4-[4-(2-pyriMidinyl)-1-piperazinyl]butyl]-, (3aR,4S,7R,7aS)-rel- (1R*,2S*,3R*,4S*)-N-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl)-2,3-norbornanedicarboximide citrate salt
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