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| CAS No. | 59865-13-3 |
| Chemical Name: | Cyclosporin A |
| Synonyms: | Neoral;s7481f1;Atopica;Cipol N;ol27-400;Restasis;Lo-27400;sandimmun;Optimmune;Neoplanta |
| CBNumber: | CB5163816 |
| Molecular Formula: | C62H111N11O12 |
| Formula Weight: | 1202.61 |
| MOL File: | 59865-13-3.mol |
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| Cyclosporin A Property |
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| solubility : |
ethanol: 30 mg/mL
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Cyclosporin A Chemical Properties,Usage,Production |
Chemical Properties
White Powder |
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Usage
prothrombogenic agent |
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Usage
Cyclosporin A is a hydrophobic cyclic peptide isolated from several fungal species including Cylindrocarpon, Fusarium, Trichoderma and Tolypocladium. Cyclosporin A inhibits T-cell activation and has been marketed since 1983 as an immunosuppressant in post-allogeneic organ transplant. Cyclosporin A acts by binding to the protein, cyclophilin (immunophilin), in T-lymphocytes causing inhibition of calcineurin (protein phosphatase 2B). Cyclosporin A reduces transcription of interleukin 2, and inhibits lymphokine production, interleukin release and NO synthesis induced by interleukin 1α, lipopolysaccharides and TNFα. |
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Usage
An immunosuppressant that has revolutionized organ transplantation through its use in the prevention of graft rejection.
A group of nonpolar cyclic oligopeptides with immunosupppressant activity. |
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General Description
White prismatic needles (from acetone) or white powder. |
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Air & Water Reactions
Slightly water soluble . |
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Reactivity Profile
Cyclosporin A is an amide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). |
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Health Hazard
SYMPTOMS: Symptoms of exposure to Cyclosporin A include hepatotoxicity, nephrotoxicity, hyperkalemia, hyperuricemia, convulsions, renal dysfunction, tremor, hirsutism, hypertension, gum hyperplasia, cramps, acne, headache, diarrhea, nausea, vomiting, abdominal discomfort, paresthesia, flushing, leukopenia, lymphoma, sinusitis and gynecomastia. In 2% or less of persons exposed, it has caused allergic reactions, anemia, anorexia, confusion, conjunctivitis, edema, fever, brittle fingernails, gastritis, hearing loss, hiccups, hyperglycemia, muscle pain, peptic ulcer, thrombocytopenia and tinnitus. Rare reactions include anxiety, chest pain, constipation, depression, hair breaking hematuria, joint pain, lethargy, mouth sores, myocardial infarction, night sweats, pancreatitis, pruritus, swallowing difficulty, tingling, upper gastrointestinal bleeding, visual disturbance, weakness and weight loss. It has caused kidney and liver damage. An increased susceptibility to infection may occur. Other symptoms include gastrointestinal disturbance, rashes and angioedema. |
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Fire Hazard
Flash point data for Cyclosporin A are not available; however, Cyclosporin A is probably combustible. |
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| Cyclosporin A Preparation Products And Raw materials |
Raw materials
Cyclosporin C
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Preparation Products
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| Cyclosporin A Suppliers Global( 228)Suppliers |
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ol27-400
s7481f1
sandimmun
sandimmune
59865-13-3
BioChemical
Antibiotics A-F
Antibiotics A to Z
Antibiotics
ANTIBIOTIC S 7481F1
ANTIBIOTIC S 7481FI
CICLOSPORIN
CICLOSPORIN A
CYCLOSPORIN A
CYCLOSPORIN A, FUSARIUM SOLANI
CYCLOSPORIN A, TOLYPOCLADIUM INFLATUM
CYCLOSPORINE
CYCLOSPORINE A
RAMIHYPHIN A
Cyclosporine, Trichoderma polysporum
Cyclosporin A USP26/EPIV
CYCLOSPORIN A, MOLECULAR BIOLOGYREAGENT
CyclosporinAfromFusariumsolani
CYCLOSPORINA(PATENTED-NOSUPPLY)
Cyclosporin A / B / C / D / H
CYCLOSPORIN USP
Active Pharmaceutical Ingredients
Organics
CYCLOSPORINE USP
Antibiotic S 7481F1, Cyclosporine
Cyclosporin A from Tolypocladium inflatum
Atopica
Neoral
Optimmune
Restasis
Intermediates & Fine Chemicals
Peptides
Pharmaceuticals
Cyclosprin
Lo-27400
Sandimmum(e)
1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane, cyclic peptide deriv.
30-Ethyl-33-(1-hydroxy-2-methyl-hex-4-enyl)-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-dipropan-2-yl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
Cipol N
Neoplanta
(3S,6S,9S,12R,15S,18S,21S,24S,30S,33S)-30-Ethyl-33-[(E,1R,2R)-1-hydroxy-2-methyl-hex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-dipropan-2-yl-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,
Protein Phosphatase
(3R,4R)-3-Hydroxy-N-methyl-5-[(E)-1-propenyl]-cyclo(L-Leu-L-Abu-Sar-N-methyl-L-Leu-L-Val-N-methyl-L-Leu-L-Ala-D-Ala-N-methyl-L-Leu-N-methyl-L-Leu-N-methyl-L-Val-)
Cicloporin A
Signalling
Cyclospori
Cyclosporin A,Antibiotic S 7481F1, Cyclosporine
CYCLOSPORIN A (ANTIBIOTIC S 7481FI)
Cyclosporine (50 mg)
Cyclosporin A(Antibiotic S 7481F1)
9865-13-3
Ciclosporin API
Cyclosporine-d4/ Cyclosporin A-d4
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