| Company Name: | Zhengzhou Topcare Pharmaceutical Co.,Ltd. Gold |
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| Email: | marketing@topcarepharm.com.cn |
| Products Intro: |
Product Name:Sunitinib Malate
CAS:341031-54-7
Purity:99% HPLC Package:1kg;5kg;25kg |
| Company Name: | Nanjing First Pharmaceutical Co., Ltd. Gold |
| Tel: | +86-25-83172655 /13776562784 |
| Email: | sales@njfirstpharm.com |
| Products Intro: |
Product Name:Sunitinib Malate
CAS:341031-54-7
Purity:>99% Package:1g;5g;10g;25g;100g;250g;500g;1kg;10kg;25kg;50kg;100kg Remarks:Available in stock |
| Company Name: | Wuhan Biocar Bio-Pharm Co., Ltd. Gold |
| Tel: | 027-86335551 |
| Email: | newbio@biocar.cn |
| Products Intro: |
Product Name:Sunitinib Mablate
CAS:341031-54-7
Purity:99% HPLC Package:1g 100/g Remarks:http://www.bio-car.cn/offer/43324444190.html |
| Company Name: | J & K SCIENTIFIC LTD. |
| Tel: | 400-666-7788 +86-10-82848833 |
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| Products Intro: |
Product Name:Sunitinib Maleate
CAS:341031-54-7
Purity:>97% Package:10Mg,1Mg,5Mg |
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| | N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate Basic information |
| Product Name: | N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate | | Synonyms: | SUNITINIB MALATE;N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate;N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidine)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide(2S)-2-hydroxybutanedioatesalt;Sunitinib Malate(Sutent);Butanedioic acid, 2-hydroxy-, (2S)-, coMpd. with N-[2-(diethylaMino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-1H-pyrrole-3-carboxaMide (1:1);N-(2-(DiethylaMino)ethyl)-5-((Z)-(5-fluoro-1,2-dih;Butanedioic acid, 2-hydroxy-, (2S)-, coMpd. with N-[2-(diethylaMino)ethyl]-5-[(Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-2,4-diMethyl-1H-pyrrole-3-carboxaMide;(Z)-N-(2-(diethylaMino)ethyl)-5-((5-fluoro-2-oxoindolin-3-ylidene)Methyl)-2,4-diMethyl-1H-pyrrole-3-carboxaMide (S)-2-hydroxysuccinate | | CAS: | 341031-54-7 | | MF: | C22H27FN4O2.C4H6O5 | | MW: | 532.566 | | EINECS: | | | Product Categories: | APIs;Heterocycles;Intermediates & Fine Chemicals;Pfizer compounds;Pharmaceuticals;Tyrosine Kinase Inhibitors;SU-11248 | | Mol File: | 341031-54-7.mol |  |
| | N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate Chemical Properties |
| | N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate Usage And Synthesis |
| Chemical Properties | Yellow Solid | | Usage | Sunitinib Malate (Sutent, SU11248) is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit. | | Usage | Sunitinib Malate is a multi-targeted RTK inhibitor targeting VEGFR2 (Flk-1) and PDGFRβ with IC50 of 80 nM and 2 nM, and also inhibits c-Kit | | Usage | A multi-kinase inhibitor targeting several receptor tyrosine kinases (RTK). Antineoplastic. | | Biological Activity | Potent, ATP-competitive VEGFR, PDGFR β and KIT inhibitor (K i values are 2, 9, 17, 8 and 4 nM for VEGFR -1, -2, -3, PDGFR β and KIT respectively). Also inhibits cellular receptor phosphorylation of FLT3, RET and CSF-1R. Exhibits antiangiogenic and antitumor activity in multiple xenograft models. |
| | N-(2-(Diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxamide (2S)-hydroxybutanedioate Preparation Products And Raw materials |
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