| |

LL-Z-1640-2

LL-Z-1640-2 Suppliers list
Company Name:J & K SCIENTIFIC LTD.  
Tel:400-666-7788 +86-10-82848833
Email:jkinfo@jkchemical.com;market3@jkchemical.com
Products Intro: Product Name:LL-Z-1640-2
CAS:66018-38-0
Package:5mg, 10mg
Company Name:3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel:86-21-50328103 * 801、802、803、804 Mobile:18930552037
Email:67055399@qq.com
Products Intro: Product Name:(5Z)-7-Oxozeaenol;(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-Methoxy-3-Methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
CAS:66018-38-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name:ChemStrong Scientific Co.,Ltd  
Tel:0755 66853366
Email:sales@chem-strong.com;
Products Intro: Product Name:LL Z1640-2;C292, L 783278
CAS:66018-38-0
Purity:>99% by HPLC Package:1Mg;5Mg
Company Name:EMMX Biotechnology LLC  
Tel:888-539-0666
Email:info@emmx.com
Products Intro: Product Name:(5Z)-7-Oxozeaenol
CAS:66018-38-0
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
LL-Z-1640-2 Basic information
Product Name:LL-Z-1640-2
Synonyms:LL-Z-1640-2;(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione;(5Z)-7-Oxozeaenol;JNK/p38 inhibitor;C292, L 783278
CAS:66018-38-0
MF:C19H22O7
MW:362.37
EINECS:
Product Categories:antibiotic
Mol File:66018-38-0.mol
LL-Z-1640-2 Structure
LL-Z-1640-2 Chemical Properties
storage temp. Desiccate at -20°C
Safety Information
Hazard Codes Xi
MSDS Information
LL-Z-1640-2 Usage And Synthesis
UsageLL Z1640-2 is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models.
Biological ActivityResorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor- β -activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC 50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF- κ B (IC 50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF- α -induced apoptosis in vitro .
LL-Z-1640-2 Preparation Products And Raw materials
Tag:LL-Z-1640-2(66018-38-0) Related Product Information
methyl 4-methoxy-2-methylbenzoate 4-Methoxysalicylic acid 2-VINYL-BENZOIC ACID ETHYL ESTER 2,4-DIHYDROXY-6-METHYLBENZOIC ACID ETHYL ESTER LL-Z-1640-2