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| CAS No. | 66018-38-0 |
| Chemical Name: | LL-Z-1640-2 |
| Synonyms: | LL-Z-1640-2;C292, L 783278;JNK/p38 inhibitor;(5Z)-7-Oxozeaenol;(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione |
| CBNumber: | CB6270733 |
| Molecular Formula: | C19H22O7 |
| Formula Weight: | 362.37 |
| MOL File: | 66018-38-0.mol |
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| LL-Z-1640-2 Property |
| storage temp. : |
Desiccate at -20°C |
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LL-Z-1640-2 Chemical Properties,Usage,Production |
Usage
LL Z1640-2 is a cis-enone resorcylic acid lactone first reported in 1978 and later rediscovered as an irreversible and highly selective TAK 1 inhibitor. TAK1 is a MAPKKK involved in the p38 signalling cascade for pro-inflammation signals such as cytokines. LL Z1640-2 effectively prevents inflammation in animal models. |
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Biological Activity
Resorcyclic lactone of fungal origin that acts as a potent and selective transforming growth factor- β -activated kinase 1 (TAK1) mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor (IC 50 = 8 nM). Displays > 33-fold and > 62-fold selectivity over MEKK1 and MEKK4 respectively. Inhibits IL-1-induced activation of NF- κ B (IC 50 = 83 nM) and JNK/p38. Inhibits production of inflammatory mediators, and sensitizes cells to TRAIL- and TNF- α -induced apoptosis in vitro . |
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| LL-Z-1640-2 Preparation Products And Raw materials |
Raw materials
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Preparation Products
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| LL-Z-1640-2 Suppliers Global( 8)Suppliers |
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| 66018-38-0(LL-Z-1640-2)Related Search: |
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LL-Z-1640-2
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LL-Z-1640-2
66018-38-0
(3S,5Z,8S,9S,11E)-3,4,9,10-tetrahydro-8,9,16-trihydroxy-14-methoxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione
(5Z)-7-Oxozeaenol
JNK/p38 inhibitor
antibiotic
C292, L 783278
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