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CAS No. | 109-99-9 |
Chemical Name: | Tetrahydrofuran |
Synonyms: | THF;PTHF;oxolan;Oxolane;PTMEG 250;NCI-C60560;Hydrofuran;PTMEG 1800;PTMEG 1400;PTMEG 1000 |
CBNumber: | CB6852795 |
Molecular Formula: | C4H8O |
Formula Weight: | 72.11 |
MOL File: | 109-99-9.mol |
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Tetrahydrofuran Property |
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density : |
1 g/mL at 25 °C
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vapor density : |
2.5 (vs air)
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vapor pressure : |
<0.01 mm Hg ( 25 °C)
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refractive index : |
n20/D 1.465
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Water Solubility : |
miscible |
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Sensitive : |
Air Sensitive & Hygroscopic |
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Stability:: |
Stable. Incompatible with halogens, strong oxidizing agents, strong reducing agents, strong bases, oxygen. May generate explosive peroxides in storage if in contact with air. Highly flammable. Store at room temperature under nitrogen. Hazardous polymerisation may occur. Light sensitive. May contain 2,6-di-tertbutyl-4-methylphenol (BHT) as a s |
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Tetrahydrofuran Chemical Properties,Usage,Production |
resin solvent
flexographic inks for plastics
coating deposition for audio and video tapes
PVC and CPVC pipe cements
polyurethane coatings
PVC film casting (food packaging) |
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reaction solvent
Grignard Reagent formation processes
pharmaceutical steroids
preparation of organometallic reagents |
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Chemical Properties
Colorless liquid |
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Usage
Suitable for HPLC, spectrophotometry, environmental testing |
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General Description
A clear colorless liquid with an ethereal odor. Less dense than water. Flash point 6°F. Vapors are heavier than air. |
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Air & Water Reactions
Highly flammable. Oxidizes readily in air to form unstable peroxides that may explode spontaneously [Bretherick, 1979 p.151-154, 164]. Soluble in water. |
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Reactivity Profile
Tetrahydrofuran reacts violently with oxidizing agents leading to fires and explosions [Handling Chemicals Safely 1980. p. 891]. Subject to peroxidation in the air. Peroxides or their products react exothermically with lithium aluminum hydride [MCA Guide for Safety 1973]. Thus, use as a solvent for lithium aluminum hydride has led to fires. Using potassium hydroxide or sodium hydroxide to dry impure Tetrahydrofuran that contains peroxides has resulted in explosions. A violent explosion occurred during the preparation of sodium aluminum hydride from sodium and aluminum in a medium of Tetrahydrofuran [Chem. Eng. News 39(40):57. 1961]. THF forms explosive products with 2-aminophenol [Lewis 3227]. |
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Health Hazard
Vapors cause nausea, dizziness, headache, and anesthesia. Liquid can de-fat the skin and cause irritation. Liquid also irritates eyes. |
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Tetrahydrofuran Preparation Products And Raw materials |
Raw materials
Polychloroprene
1,4-Butanediol
Nickel
2-CHLORO-1,3-BUTADIENE
IRISH MOSS
PALLADIUM-CATALYSTS
Hydrogen
Metallic oxides
cis-1,4-Dichloro-2-butene
gamma-Butyrolactone
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Preparation Products
Jiuma plate amino-acid surfactant
SODIUM PHENOLATE TRIHYDRATE
Norethindrone
4-TERT-BUTYLBENZYL ALCOHOL
1-(2-NAPHTHYL)METHANAMINE
9-Anthracenemethanol
Chiral 2,2-Disubstituted thiaprolinol derivatives
(R)-TERT-LEUCINOL
2-(4-tert-Butylphenyl)ethanol
1,4-Butane sultone
Erythromycin ethylsuccinate
3-tert-butyl-1H-1,2,4-triazole-5-thiol
N-methylaminoethanol sodium phosphate
4-Amino-5-bromo-2-chloropyrimidine
1,4-Diiodobutane
L(+)-Leucinol
2-Chloroisonicotinaldehyde
Benzyldimethylhexadecylammonium chloride
(S)-(-)-4-tert-Butyloxazolidine-2,5-dione
7-Fluoroindole
L-Tryptophanol
4-Chlorobutylbenzoate
TERT-BUTYLMAGNESIUM CHLORIDE
alpha,alpha-Diphenyl-L-prolinol
BENZO[B]THIOPHENE-2-CARBOXALDEHYDE
2,5-Dimethylpiperazine
Quinestrol
Allylmagnesium chloride
Levonorgestrel
N-(2-Aminoethyl)piperidine
2,3,4-Tribromothiophene
(4-AMINO-PYRIDIN-3-YL)-METHANOL
3-Cyanophenylboronic acid
Dioctyl(maleate)tin
Cyclopropylacetic acid
2,3-Difluorophenylboronic acid
2,2'-DIPYRIDYLAMINE
Vinylferrocene
Tetrahydrothiophene
(1,5-DIMETHYL-1H-PYRAZOL-3-YL)METHANOL
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Tetrahydrofuran Suppliers Global( 315)Suppliers |
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1,4-epoxy-butan
agrisynththf
Butane alpha,delta-oxide
Butane, 1,4-epoxy-
butane,alpha,delta-oxide
butanealpha,delta-oxide
Dynasolve 150
Hydrofuran
NCI-C60560
Oxacyclopentane
oxolan
Oxolane
QO Tetrahydrofuran (THF)
Rcra waste number U213
rcrawastenumberu213
tetrahydro-fura
Tetrahydrofuraan
Tetrahydrofurane
Tetrahydrofuranne
tetrahydrofuranne(french)
Tetraidrofurano
THF (tetrahydrofuran)
109-99-9
Biotech Solvents
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Amino Acid Analysis Reagents
Amino Acids and Peptides
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Biochemicals and Reagents
Building Blocks
ALPHA-HYDRO-OMEGA-HYDROXYPOLY(OXY-1,4-BUTANEDIYL)
TETRAMETHYLENE ETHER GLYCOL 650 POLYMER
TETRAMETHYLENE ETHER GLYCOL 1000 POLYMER
TETRAMETHYLENE ETHER GLYCOL 2900 POLYMER
TETRAMETHYLENE ETHER GLYCOL 2000 POLYMER
TA - TE
Tetrahydrofuran (THF)
Returnable Container Solvents
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Polyols
POLB - POLY
Oxygen Compounds
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CHROMASOLV® Plus
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Organic Building Blocks
PTHF
PTMEG 1800
PTMEG 1400
PTMEG 1000 S
PTMEG 1000
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